Clinical and biological significance of chromosome aberrations in leukemia and lymphoma
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Balanced translocations affecting the l lq23 region are among the most frequent chromosomal abnormalities in childhood acute lymphoblastic leukemia (ALL), comprising 5% to 6%. These cases consistently have a rearranged MLL gene and are associated with high-risk presenting features, hyperleukocytosis and younger age, and a poor treatment outcome. To assess the clinical and biologic significan...
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تاریخ انتشار 2017